A. Describe your advisory firm, including how long you have been in business. Identify your principal owner(s). Sio Capital Management, LLC is a Delaware limited liability company, legally formed on March 2, 2006. Dr. Michael Castor is the Firm’s sole principal owner and has served as head portfolio manager since inception. B. Describe the types of advisory services you offer. If you hold yourself out as specializing in a particular type of advisory service, such as financial planning, quantitative analysis, or market timing, explain the nature of that service in greater detail. If you provide investment advice only with respect to limited types of investments, explain the type of investment advice you offer, and disclose that your advice is limited to those types of investments. Sio provides discretionary investment advisory services to private investment vehicles (the “Funds”), which are exempted from registration under federal securities laws. The Funds generally employ a similar investment strategy. Sio provides discretionary investment advisory services to the following pooled investment vehicles:
• Sio Partners, LP (3c1); and
• Sio Partners Offshore Ltd. (3c7). In addition, Sio advises five separately managed accounts (each an “SMA”; collectively, the “SMAs”) for institutional clients. Collectively, the Funds and SMAs are referred to herein as the “Clients.” Limited partners, shareholders, and investors in the Clients are referred to herein as “Investors.” Sio GP, LLC, an affiliate of Sio, serves as the general partner (“General Partner”) to Sio Partners, LP. Sio Partners, LP is organized as a limited partnership. Sio Partners Offshore Ltd. is a non-U.S. fund (“Offshore”) and is overseen by a Board of Directors (“Board”). C. Explain whether (and, if so, how) you tailor your advisory services to the individual needs of clients. Explain whether clients may impose restrictions on investing in certain securities or types of securities. Sio provides discretionary investment advisory services to the Clients, defined as giving continuous advice to a Client or making investments for a Client based on the individual needs of the Client. The needs of any particular Client are generally identified through a review of the Client’s investment guidelines, strategies, and specific investment goals. Sio does not tailor its advisory services, investment objectives, or strategies to the requests or needs of individual investors. For the avoidance of doubt, Sio’s Clients are its

Funds and SMAs and not the underlying investors in the Funds and SMAs. Thus, the Funds and SMAs may impose restrictions on Sio with respect to investing in certain securities or types of securities, but Investors are not permitted to restrict investments. Sio may from time to time enter into side letters or other similar agreements with one or more Investors in the Funds that provide such Investor(s) with additional or different rights (including, without limitation, with respect to the management fee, the performance fee/allocation, access to information, minimum investment amounts and liquidity terms) than such Investor(s) have pursuant to a Client’s offering documents. As outlined in each Client’s confidential private offering memorandum, limited partnership agreement, investment management agreement, or other governing documents as applicable (collectively the “Offering Documents”), Sio will not be required to notify any or all of the Investors of any such written agreement or any of the rights or terms or provisions thereof, nor will Sio and/or General Partner be required to offer such additional and/or different rights and/or terms to any or all of the other Investors. For more detailed information regarding each Client’s restrictions, refer to the Client’s Offering Documents. D. If you participate in wrap fee programs by providing portfolio management services, (1) describe the differences, if any, between how you manage wrap fee accounts and how you manage other accounts, and (2) explain that you receive a portion of the wrap fee for your services. Sio does not participate in wrap fee programs. E. If you manage client assets, disclose the amount of client assets you manage on a discretionary basis and the amount of client assets you manage on a non-discretionary basis. Disclose the date “as of” which you calculated the amounts. Note: Your method for computing the amount of “client assets you manage” can be different from the method for computing “regulatory assets under management” required for Item 5.F in Part 1A. However, if you choose to use a different method to compute “client assets you manage,” you must keep documentation describing the method you use. The amount you disclose may be rounded to the nearest $100,000. Your “as of” date must not be more than 90 days before the date you last updated your brochure in response to this Item 4.E. As of December 31, 2023, Sio managed discretionary client assets of $1,405,889,917. Sio does not manage assets on a non-discretionary basis.